血管生成
柚皮苷
骨愈合
医学
骨质疏松症
刺激
癌症研究
药理学
内科学
内分泌学
化学
外科
色谱法
作者
Nan Song,Zhihu Zhao,Xiaofang Ma,Xiaolei Sun,Jianxiong Ma,Fengbo Li,Lei Sun,Jianwei Liu
标识
DOI:10.1016/j.cbi.2016.10.020
摘要
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.
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