Peptidic Amidomonophosphane Ligand for Copper‐Catalyzed Asymmetric Conjugate Addition of Diorganozincs to Cycloalkenones

Abstract Peptidic modification of ( S )‐2‐[(diphenylphosphino)methyl]pyrrolidine gave a dipeptide‐connected amidomonophosphane ligand for the highly efficient, copper‐catalyzed asymmetric conjugate addition reaction of organozinc reagents with cycloalkenones, giving 3‐alkylated cycloalkanones in high enantioselectivity of up to 98 % ee . A model that predicts the stereochemistry of the reaction is discussed.