Palladium nanoparticles as reusable catalyst for the synthesis of N-aryl sulfonamides under mild reaction conditions

AbstractAn efficient palladium nanoparticles-catalyzed N-arylation of sulfonamides and sulfonyl azides is described. This procedure serves as an active protocol for intermolecular C–N bond formation using Pd(OAc)2 in PEG-400 under air. Aryl bromides and triflates react at 35°C, while aryl chlorides require heating to 50°C and give the desired products only in low yields. This reaction proceeds smoothly in acceptable yields using low catalyst loading.KEYWORDS: Sulfonamidearyl halidearyl triflatepalladium nanoparticlesC–N Cross-coupling AcknowledgementsWe also gratefully acknowledge from the Iranian Nano Council for the support of this work.Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis work was supported by the Islamic Azad University of IRAN, Buinzahra branch (research grant).