肽核酸
核酸
肽
信使核糖核酸
化学
核糖核酸
银纳米粒子
分子生物学
核苷酸
纳米颗粒
基因
生物化学
生物
纳米技术
材料科学
作者
Xia Li,Juan Song,Baoli Chen,Bing Wang,Rui Li,Huimin Jiang,Jifeng Liu,Chen-Zhong Li
标识
DOI:10.1007/s11434-016-1004-3
摘要
A label-free colorimetric protocol based on peptide nucleic acid/silver nanoparticles (PNA/AgNPs) has been initially proposed for specific recognition of mRNA. Making use of the controlled silver nanoparticles aggregation/dispersion by PNA/PNA–RNA complex, proto-oncogene c-Myc mRNA detection can be achieved. Moreover, the PNA/AgNPs platform can undergo color change in response to target c-Myc mRNA with single-base-mismatch sensitivity, which could further help in visually identify single nucleotide differences in target genes.
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