医学
生物标志物
小RNA
内科学
诊断生物标志物
接收机工作特性
肿瘤科
胃肠病学
作者
Jiyou Yao,Ka Yin Lui,Xiaoguang Hu,En-he Liu,Tingting Zhang,Li Tong,Jinghong Xu,Fa Huang,Yanping Zhu,Minqiang Lu,Chang-jie Cai
标识
DOI:10.1016/j.meegid.2021.105082
摘要
Abstract This study was to find out novel miRNAs whether could be used as diagnostic or prognostic biomarkers in sepsis. We used miRNAs microarray assays and further confirmed the levels of miRNAs in 151 septic patients' plasma. 56 miRNAs were up-regulated and 74 miRNAs down-regulated in septic patients compared with the healthy volunteers. But only miR-519c-5p and miR-3622b-3p were up-regulated in both septic and septic shock patients. The levels of miR-519c-5p and miR-3622b-3p were statistically higher in 151 septic patients than healthy controls on day 1. The AUC for miR-519c-5p was 0.79 (95% CI, 0.688–0.892, p = 0.001) in the diagnosis of sepsis, and the AUC for miR-3622b-3p 0.752 (95% CI, 0.622–0.881, p = 0.003). The AUC for the combination of these two miRNAs was 0.831 (95% CI, 0.74–0.923, p Clinical trial registration information Name of the registry: Diagnostic and prognostic value of circulating miRNA in patients with sepsis; Trial registration ID: ChiCTR-DDD-17013150; registered 30 October 2017; http://www.chictr.org.cn/edit.aspx?pid=22528&htm=4 .
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