医学
药物输送
药品
肝移植
3d打印
体内
肝病
肝衰竭
药理学
可用性
加药
移植
生物医学工程
外科
内科学
材料科学
生物
纳米技术
计算机科学
生物技术
人机交互
作者
Shinyoung Kim,Ginam Han,Da-Bin Hwang,Dong‐Hoon Won,Yoo-Sub Shin,Changuk Kim,Jeon Min Kang,Jung Hoon Park,Hyun‐Do Jung,Wooram Park,Jun-Won Yun
标识
DOI:10.1002/adhm.202100497
摘要
Abstract Acute liver failure (ALF) requiring liver transplantation is a disease that occurs due to rapid hepatocellular dysfunction. As liver transplantation has various limitations, including donor scarcity, high cost, and immuno‐incompatibility, continuous local delivery of biopharmaceuticals to the liver tissue can be a promising ALF treatment option. Here, the in vivo safety and usability of a 3D‐printed implantable drug delivery device for effective ALF treatment is evaluated. The implantable reservoir consists of a 3D‐printed container and a semipermeable membrane for repeated administrations of drugs, specifically to the liver tissue. The physical stability and function of the 3D‐printed reservoir are confirmed by the mechanical properties and in vitro drug release test, respectively. In mice implanted with the reservoir system, mortality, weight changes, clinical signs, hematological and serum biochemical changes, and organ weight changes are not observed, suggesting no foreign body reaction. The usability of the reservoir system is further evaluated using an ALF model of 70% hepatectomized mice treated with N ‐acetylcysteine through the system, showing cell‐specific regeneration and significant liver injury alleviation. Overall, the 3D‐printed reservoir system is safe for studying the therapeutic potential of ALF treatment, and it can be used for the delivery of various active pharmaceutical ingredients.
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