This chapter introduces Mycobacterium tuberculosis , the agent that causes tuberculosis and the drugs (first- and second-line) for tuberculosis treatment as well as the effects of phytochemicals against Mycobacterium tuberculosis . It starts by giving an overview of the organism and the disease burden of tuberculosis. It then explains the potential plants with antimycobacterial properties, phytochemicals/plant metabolites against Mycobacterium tuberculosis as well as phytochemicals against multidrug resistant tuberculosis. At the end of this chapter, the therapeutic potential of phytochemicals against Mycobacterium tuberculosis was discussed. A discussion on phenolic compounds as potential drugs for tuberculosis and prospects of phytochemicals against Mycobacterium tuberculosis was included.