Objective:To analyze the clinical characteristics of Kawasaki disease in the infants less than 6 months old which lead to early observation and diagnosis of KD in infants and decrease the incidence of coronary complications.Methods:Retrospective analysis of clinic data of 26 KD infants less than 6 months old from January 2005 to May 2010 in our hospital were done.Results:The clinic characteristics of KD in infants less than 6 months old were atypical,most of them presented incompletely and the coronary artery always were injured.Long time was spent to diagnose and many were misdiagnosed.Conclusion:It is the only way for early diagnosis KD in infants that coronary artery was monitored in suspicious patients.Infants less than 6 months old should be suspicious of KD who had fever lasting for at least 5 days with unknown reasons and the treatment is not efficient.It could lead to early diagnosis and improve prognosis.