Following the coronary recanalization surgery,therapeutic angiogenesis is becoming a hot spot to the basic and clinical research of the coronary heart disease. The angiogenesis factors are complex,so the clinical trial results obtained by therapeutic angiogenesis are not the same. In order to help the basic and clinical angiogenesis research of coronary heart disease,this article combined with angiogenesis factors analyzes a number of methods for enhancing angiogenesis effects and the possible reasons of reducing the efficacy and sums up the clinical research of the coronary therapeutic angiogenesis.