Protective effect of intestinal probiotics on intestinal mucosa of patients with loss compensatory stage of cirrhosis

Objective: To investigate the protective effect of intestinal probiotics on intestinal mucosa of patients with loss compensatory stage of cirrhosis. Methods: Eighty-two cases of patient with loss compensatory stage of cirrhosis were selected and randomly divided into observation group and control group,in each group there were 41 cases,normal group where there were 40 cases was set. Patients in control group were treated with conventional therapy,and patients in observation group were treated with intestinal probiotics on basis of control group,and normal group were not done any treatment,the changes of intestinal permeability,ETX level,intestinal flora before or after treatment among three groups were compared. Results: Before treatment,the LAC,LAC / MAN,ETX in observation group and control group were higher than those in normal group,the MAN was lower than that in normal group( P 0. 05),the intestinal bifidobacterium,lactobacillus,bacteroides in observation group and control group were significantly lower than those in normal group,the clostridium,enterobacter,yeast-like fungi were increased significantly( P 0. 05); after treatment,the LAC,LAC / MAN,ETX were lower than those in control group( P 0. 05),the bifidobacterium,lactobacillus,bacteroides,enterococcus in observation group were significantly higher than those in control group,the intestinal bacteria,yeasts were significantly lower than those in control group( P 0. 05). Conclusion: Intestinal probiotics can significantly improve the intestinal permeability of patients with loss compensatory stage of cirrhosis,reduce ETX production,at the same time,improve intestinal flora microecology balance,repair intestinal mucosa barrier,and then improve patient's prognosis,it is worthy of clinical application.