Studies on the absorption kinetics of different purities of puerarin in rats' intestine

OBJECTIVE To study the impact of the absorption kinetics of different purities of puerarin extracts in rats'intestine.METHODS Rats were cannulated for in situ recirculation,HPLC was used to determine the parameters of the absorption kinetics of different purities of puerarin extracts.RESULTS With the increase of the purity,the absorption rate constant of different purities of puerarin was decreased,the half-life delayed,and the accumulated absorption rate decreased.The absorption of different purities of puerarin in rats was a first-order process.CONCLUSION The exorbitant purity of puerarin is not conducive to its intestinal absorption.