Effect of Er Xian decoction on ovary function after injury of cisplatin in mice

[Objective] To investigate the regulatory effect of Er Xian decoction on restoring ovary function in premature ovarian failure(POF) in mice injured by cisplatin(CDDP).[Methods] Female SD mice were given with cisplantin daily to set up the model of POF.The changes of genital hormones,ovulation,MDA,T-AOC and ovary morphology were observed in mice after intragastric administration of Er Xian decoction.[Results] Compared with model group,in the Er Xian decoction group FSH and LH decreased,E2and P increased,MDA decreased and T-AOC increased in ovary tissue,less follicular atresia and intercellular substance presented,the fibrous degeneration of ovaries were ameliorated.[Conclusion] Er Xian decoction can restrain oxidative injury,reduce the formation of extracellular matrix and promote its degradation,thus can restore the function of follicle and granulocyte and improve ovary function.