To achieve the cultivation of innovative talents,many domestic universities implement research-based teaching reforms.Using the path dependence theory of economics,the paper summarizes the reasons for reform producing path dependence,namely sensitivity to starting point,the feature of efficiency-driven and the locked equilibrium during the process of research-based teaching reform.Using the influence of the external resources change,we must pay attention to the strategic behavior of teachers,students and education administrators to deviate from the path.These path creation activities are more important to realize the leap-forward development of research-based teaching reform.