化学
脱质子化
分子内力
催化作用
戒指(化学)
化学计量学
组合化学
基础(拓扑)
氢键
硝基
药物化学
氧化还原
内酰胺
立体化学
有机化学
分子
数学分析
离子
烷基
数学
作者
Karen Thai,Li Wang,Travis Dudding,François Bilodeau,Michel Gravel
出处
期刊:Organic Letters
[American Chemical Society]
日期:2010-11-16
卷期号:12 (24): 5708-5711
被引量:61
摘要
A very efficient NHC-catalyzed lactamization reaction is reported. For most cases, the ring expansion reaction proceeds to cleanly furnish five- and six-membered N-Ts and N-Bn lactams, without the need for further purification. Evidence is presented suggesting a dual role for the stoichiometric base: (1) deprotonation of the triazolium precatalyst and (2) activation of the nitrogen leaving group through hydrogen bonding.
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