多细胞生物
生物
干细胞
概念
胚胎
计算生物学
翻译(生物学)
构造(python库)
神经科学
计算机科学
细胞生物学
认知科学
细胞
遗传学
心理学
基因
信使核糖核酸
妊娠期
程序设计语言
怀孕
作者
Jianping Fu,Aryeh Warmflash,Matthias P. Lütolf
出处
期刊:Nature Materials
[Springer Nature]
日期:2020-11-16
卷期号:20 (2): 132-144
被引量:100
标识
DOI:10.1038/s41563-020-00829-9
摘要
Despite its importance, understanding the early phases of human development has been limited by availability of human samples. The recent emergence of stem-cell-derived embryo models, a new field aiming to use stem cells to construct in vitro models to recapitulate snapshots of the development of the mammalian conceptus, opens up exciting opportunities to promote fundamental understanding of human development and advance reproductive and regenerative medicine. This Review provides a summary of the current knowledge of early mammalian development, using mouse and human conceptuses as models, and emphasizes their similarities and critical differences. We then highlight existing embryo models that mimic different aspects of mouse and human development. We further discuss bioengineering tools used for controlling multicellular interactions and self-organization critical for the development of these models. We conclude with a discussion of the important next steps and exciting future opportunities of stem-cell-derived embryo models for fundamental discovery and translation.
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