微气泡
从长凳到床边
药物输送
计算机科学
纳米技术
全身循环
医学
医学物理学
风险分析(工程)
材料科学
超声波
放射科
内科学
作者
Eleanor Stride,Tim Segers,Guillaume Lajoinie,Samir Cherkaoui,Thierry Bettinger,Michel Versluis,Mark A. Borden
标识
DOI:10.1016/j.ultrasmedbio.2020.01.027
摘要
Microbubble ultrasound contrast agents have now been in use for several decades and their safety and efficacy in a wide range of diagnostic applications have been well established. Recent progress in imaging technology is facilitating exciting developments in techniques such as molecular, 3-D and super resolution imaging and new agents are now being developed to meet their specific requirements. In parallel, there have been significant advances in the therapeutic applications of microbubbles, with recent clinical trials demonstrating drug delivery across the blood–brain barrier and into solid tumours. New agents are similarly being tailored toward these applications, including nanoscale microbubble precursors offering superior circulation times and tissue penetration. The development of novel agents does, however, present several challenges, particularly regarding the regulatory framework. This article reviews the developments in agents for diagnostic, therapeutic and “theranostic” applications; novel manufacturing techniques; and the opportunities and challenges for their commercial and clinical translation.
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