活性氧
细胞内
纳米囊
肿瘤微环境
谷胱甘肽
生物物理学
体内
纳米载体
肿瘤缺氧
光动力疗法
体外
癌症研究
化学
细胞生物学
纳米颗粒
材料科学
纳米技术
肿瘤细胞
生物化学
生物
酶
有机化学
放射治疗
生物技术
内科学
医学
作者
Shiyan Fu,Ruihao Yang,Lei Zhang,Weiwei Liu,Guangyuan Du,Yang Cao,Zhigang Xu,Hongjuan Cui,Yuejun Kang,Peng Xue
出处
期刊:Biomaterials
[Elsevier]
日期:2020-10-01
卷期号:257: 120279-120279
被引量:97
标识
DOI:10.1016/j.biomaterials.2020.120279
摘要
Chemodynamic therapy (CDT), an emerging therapeutic strategy, has been recently exploited for in situ treatment through Fenton or Fenton-like reactions to generate cytotoxic reactive oxygen species (ROS). However, current systems rely significantly on the high local oxygen levels and strongly acidic conditions (pH = 3.0–5.0). Simultaneously, the produced ROS can be rapidly consumed by intracellular glutathione (GSH) in the electron transport chain. Herein, an original and biomimetic [email protected] nanocatalyst was prepared based on the assembly of Au and Pt nanoparticles (NPs) on the surface of hollow CoO nanocapsules. The as-synthesized nanozyme exhibits extremely high stability under physiological conditions, whereas it undergoes spontaneous disintegration in the unique tumor microenvironment (TME). Subsequently, the decomposition products can catalyze a cascade of biochemical reactions to produce abundant ROS without any external stimuli. Thus, the present nanoplatform can increase intracellular ROS levels through continuous supply of H2O2, relief of local hypoxia and depletion of GSH, which result in remarkable and specific tumor damage both in vitro and in vivo. The findings of this study highlight the promising potential of [email protected] nanocatalyst as a TME-responsive CDT nanomagnet for highly efficient tumor therapy.
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