In this paper, the design optimization of structures with stress constraints is performed using isogeometric shape optimization method. The stress constraints have an important role in design optimization problems since stress concentration could result in structural failure. To represent exact geometry in analysis, the isogeometric analysis method uses the same basis functions as used in the CAD geometry. The geometrically exact model can be used in both stress and design sensitivity analyses so that it can yield more precise optimal design than finite element one. Through numerical examples, the isogeometric approach turns out to be effective in shape optimization problems under stress constraints.