Iron-catalyzed clean dehydrogenative coupling of alcohols with P(O)–H compounds: a new protocol for ROH phosphorylation

An efficient oxygen-phosphoryl bond-forming reaction via iron-catalyzed cross dehydrogenative coupling has been developed. This transformation proceeds efficiently under oxidant- and halide-free reaction conditions with H₂ liberation, and represents a straightforward method to prepare valuable organophosphoryl compounds from the readily available alcohols and P(O)-H compounds.