Studies on the trichloroethylene metabolism and storage of urinary trichloroethylene metabolites

To defermine the mutual metabolic inhibition of trichloroethylene and ethanol, experiments were conducted on mice.Mice were injected both solvents at 60 minutes intervals intraperitoneally, and 30 or 45 minutes after the final injection, concentration of both solvents in the blood and organs were determined.Mice were preliminarily administered trichloroethylene intraperitoneally (131mg/Kg) and ethanol (500mg/Kg). The ethanol concentrations in blood, brain and livers of mice administered with trichloroethylene were higher than those in the respective organs of mice without trichloroethylene.When the mice were administered ethanol followed by trichloroethylene the concentration of trichloroethylene in mice given ethanol was higher than that of in mice not given ethanol injection.