胶质毒素
真菌
立体化学
烟曲霉
曲霉
结核分枝杆菌
化学
细胞毒性
微生物学
二维核磁共振波谱
生物
肺结核
生物化学
植物
体外
医学
病理
作者
Xiaowei Luo,Xuefeng Zhou,Xiuping Lin,Xiaochun Qin,Tianyu Zhang,Junfeng Wang,Zhengchao Tu,Bin Yang,Shengrong Liao,Yongtao Tian,Xiaoyan Pang,Kumaravel Kaliyaperumal,Jian Lin Li,Huaming Tao,Yonghong Liu
标识
DOI:10.1080/14786419.2016.1266353
摘要
Eleven diketopiperazine and fumiquinazoline alkaloids (1–11) together with a tetracyclic triterpenoid helvolic acid (12) were obtained from the cultures of a deep-sea derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of these compounds (1–12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated. Gliotoxin (3), 12,13-dihydroxy-fumitremorgin C (11) and helvolic acid (12) exhibited very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50 values of <0.03, 2.41 and 0.894 μM, respectively, which was here reported for the first time. Meanwhile gliotoxin also displayed significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4 μM, respectively.
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