4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies

Background: Cancer is one of the most serious clinical problems worldwide, and considerable efforts have been devoted to discovering therapeutic agents with novel modes of action. Natural and synthetic coumarin derivatives have attracted intense research interest due to their diverse structural features and remarkable array of biological properties. Keywords: 4-Methylumbelliferones, urea/thioureas piperazine, cytotoxicity, apoptosis, cell cycle.