A 67-year-old man with known prostate carcinoma presented with aches and pain. It recurred with diffuse bone metastases but no detectable prostate-specific antigen (PSA)2 in the serum. Biopsies revealed prostatic adenocarcinoma with Gleason score 7 and metastatic prostatic carcinoma of bone marrow and lymph nodes. He had responded previously to chemotherapy and radium-223 as …