Synthesis, Characterization and Antimicrobial Screening of Novel Ortho Hydroxy Chalcones

The chalcones (1, 3-diaryl-2-propenones) and their derivatives are important intermediates in organic synthesis (Straub, 1995; Sandler and Karo, 1972; Bergman Bergman et al., 1959). They serve as starting material for the synthesis of variety of heterocyclic compounds which are of physiological importance. Due to the presence of enone functionality in chalcone moiety confers biological activity upon it, like anti inflammatory anti-bacterial (Chikhalia et al., 2008), anticancer (Kotra et al., 2010), cytotoxic activity (Go et al., 2005), anti-hyperglycemic (Satyanarayana et al., 2004), (Ballesteros et al., 1995), antifungal, (Go et al., 2005), antioxidant (Mukerjee Mukerjee et al., 2001), antimalarial (Liu et al., 2003), antituberculosis (Sivakumar et al., 2007), analgesic (Sivakumar et al., 2003), anti HIV International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 3(2016) pp. 785-791 Journal homepage: http://www.ijcmas.com