橙皮素
索拉非尼
药理学
细胞凋亡
医学
神经毒性
肝细胞癌
毒性
化学
抗氧化剂
癌症研究
内科学
生物化学
类黄酮
作者
Dalia Zaafar,Heba M. A. Khalil,Reham Abdelrahman Elnaggar,Diana Z. Saad,Mohamed S. Elshikh
出处
期刊:Life Sciences
[Elsevier]
日期:2024-01-01
卷期号:336: 122295-122295
被引量:1
标识
DOI:10.1016/j.lfs.2023.122295
摘要
Sorafenib, an FDA-approved standard chemotherapy for advanced hepatocellular carcinoma, is associated with numerous adverse effects that significantly impact patients' physiological well-being. Consequently, identifying agents that mitigate these side effects while enhancing efficacy is crucial. Hesperetin, a flavone present in fruits and vegetables, possesses antioxidant, anti-inflammatory, and anti-cancer properties. This study aimed to investigate the hepatotoxic and neurotoxic effects of sorafenib and the potential protective role of hesperetin.Swiss albino mice were orally administered sorafenib (100 mg/kg) alone or in combination with hesperetin (50 mg/kg) over 21 days. Behavioral assessments for anxiety and depressive-like behaviors were conducted. Additionally, evaluations encompassed apoptotic activity, mitochondrial integrity, liver enzyme levels, proliferation rates, and histopathological changes.Combining hesperetin with sorafenib showed improvements in behavioral alterations, liver damage, brain mitochondrial dysfunction, and liver apoptosis compared to the sorafenib-only group in mice.Hesperetin exhibits potential as an adjunct to sorafenib, mitigating its side effects by attenuating its toxicity, enhancing efficacy, and potentially reducing the occurrence of sorafenib-induced resistance through the downregulation of hepatocyte growth factor levels.
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