Iron‐Catalyzed, Light‐Driven Decarboxylative Oxygenation

Abstract An iron‐catalyzed, visible light‐driven, dioxygen mediated decarboxylative oxygenation of carboxylic acids is disclosed. The catalytic system based on naturally existing Mohr salt and simple di(2‐picolyl)amine ligand is readily available and inexpensive. The applicability of the method was demonstrated through the efficient and selective synthesis of a range of ketones, aldehydes and amides including drug derivatives. Based on experimental investigations, a hypothetical mechanism was proposed.