癌症研究
前列腺癌
PTEN公司
免疫检查点
癌症
肿瘤微环境
医学
免疫系统
PI3K/AKT/mTOR通路
免疫疗法
生物
信号转导
内科学
免疫学
细胞生物学
肿瘤细胞
作者
Kiranj Chaudagar,Hanna M. Hieromnimon,Anne Kelley,Brian Labadie,Jordan Shafran,Srikrishnan Rameshbabu,Catherine Drovetsky,Kaela Bynoe,Ani Solanki,Erica Markiewicz,Xiaobing Fan,Massimo Loda,Akash Patnaik
标识
DOI:10.1158/1078-0432.ccr-23-1441
摘要
Abrogation of lactate-mediated cross-talk between cancer cells and TAM results in durable ADT-independent tumor control in PTEN/p53-deficient AVPC, and warrants further investigation in clinical trials.
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