医学
对乙酰氨基酚
麻醉
止痛药
重症监护室
插管
镇静
镇静剂
类阿片
重症监护医学
内科学
受体
作者
Asahiko Higashitsuji,Y. Tomioka,Tomoaki Tanabe,Noam Ami,Imun Tei
出处
期刊:Journal of opioid management
[Weston Medical Publishers]
日期:2023-08-11
卷期号:19 (4): 291-299
标识
DOI:10.5055/jom.2023.0786
摘要
After cardiovascular surgery, analgesic and sedative management in the intensive care unit (ICU) significantly affects short- and long-term outcomes of patients. This study aimed to clarify the impact of opioid reduction after acetaminophen administration on the length of intubation and rescue analgesic use after cardiovascular surgery.This was a case-control study.This study was conducted in the ICU of a cardiovascular hospital.Datasets of 556 post-cardiac surgery participants were collected; for final analyses, 266 participants were selected by propensity score matching. Equality between the intervention and comparison groups was ensured by calculating the standardized difference and difference test.The intervention group was treated with the multimodal analgesic sedation protocol.The primary outcomes were the length of intubation and use of rescue analgesics.The intervention group demonstrated a decreased total opioid consumption (460.0 vs 580.0 mcg, effect size [ES] = -0.178), opioid administration time (1,130.0 vs 2,070.0 minutes, ES = -0.306), and sedative administration time (955.0 vs 1,577.0 minutes, ES = -0.354). Moreover, the protocol resulted in decreased duration of ventilation (990.0 vs 1,057.5 minutes, ES = -0.140) and reduced need for rescue analgesics, including flurbiprofen axetil (3.5 vs 34.5 percent, ES = -0.392) and loxoprofen sodium (19.5 vs 48.1 percent, ES = -0.284).This study suggested that acetaminophen reduces opioid use and improves patient outcomes after cardiovascular surgery. Moreover, this research provides essential information for developing analgesic management strategies to reduce opioid consumption in patients after cardiovascular surgery.
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