干细胞
造血
造血干细胞
免疫学
白血病
生物
癌症研究
医学
细胞生物学
作者
Patricia A. Colom Díaz,Jayna J. Mistry,Jennifer J. Trowbridge
出处
期刊:Blood
[American Society of Hematology]
日期:2023-08-10
卷期号:142 (6): 533-542
被引量:5
标识
DOI:10.1182/blood.2022017933
摘要
Abstract With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate, differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to dysfunctional hematopoiesis, the incidence of hematologic malignancies increases among elderly individuals. Here, we provide an update on HSC-intrinsic and -extrinsic factors and processes that were recently discovered to contribute to the functional decline of HSCs during aging. In addition, we discuss the targets and timing of intervention approaches to maintain HSC function during aging and the extent to which these same targets may prevent or delay transformation to hematologic malignancies.
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