Currently, the recognition that dupilumab may be beneficial for the management of alopecia areata in severe atopic dermatitis patient is seemingly spreading. At the same time, worsening of alopecia areata during dupilumab treatment has also been noted as presented in this report. This study alert physicians that use if dupilumab in expectation of alopecia areata improvement in alopecia areata concomitant with atopic dermatitis cases can lead to unfortunate consequence in some patients.