化学
吡啶
组合化学
范围(计算机科学)
脚手架
分子
环加成
立体化学
有机化学
数据库
催化作用
计算机科学
程序设计语言
作者
Xiao‐Long He,You-Wu Wen,Hechen Li,Shan Qian,Mengyang He,Qiao Song,Zhouyu Wang
标识
DOI:10.1021/acs.joc.2c02495
摘要
Spiroindolizidine oxindoles represent a kind of privileged scaffold in many biologically active natural alkaloids. 2,3-Dihydrobenzofuran derivatives exhibit significant bioactivities in a variety of pharmaceuticals. Herein, we assembled these two privileged fragments into a small molecule via double-dearomative [3 + 2] cycloadditions with pyridinium ylides and 2-nitrobenzofurans. This protocol features remarkable advantages including wide substrate scope, mild condition, high level of diastereoselectivities and yields. Thus, a collection of spiroindolizidine-fused dihydrobenzofurans/indolines were facilely produced efficiently.
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