机制(生物学)
冷凝
建筑
相(物质)
功能(生物学)
染色体
生物
细胞生物学
物理
遗传学
历史
热力学
量子力学
基因
考古
作者
J. G. Park,Jeong-Jun Kim,Je-Kyung Ryu,Je-Kyung Ryu,Je-Kyung Ryu,Je-Kyung Ryu,Je-Kyung Ryu
标识
DOI:10.1038/s12276-024-01226-x
摘要
Abstract Chromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this process has left its molecular mechanism unclear. Here, we introduce the principles governing phase separation and its connections to physiological roles in this context. Our primary focus is contrasting two phase separation mechanisms: self-association-induced phase separation (SIPS) and bridging-induced phase separation (BIPS). We provide a comprehensive discussion of the distinct features characterizing these mechanisms and offer illustrative examples that suggest their broad applicability. With a detailed understanding of these mechanisms, we explore their associations with nucleosomes and chromosomal biological functions. This comprehensive review contributes to the exploration of uncharted territory in the intricate interplay between chromosome architecture and function.
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