Regulatory T-cells in autoimmune hepatitis: An historical perspective with hints to the future

We have read with interest the review by Fleming and colleagues, who discuss the central role of regulatory T-cells (Tregs) in the maintenance of immunotolerance in autoimmune liver diseases and liver transplantation.1 We would like to raise a few points for discussion, focusing specifically on autoimmune hepatitis (AIH), as these may be relevant for future studies investigating the role of Tregs in AIH pathogenesis and for the development of immune therapies aimed at reconstituting this immunomodulatory cell subset.