癌症
疾病
癌症治疗
医学
人类健康
人类疾病
生物技术
重症监护医学
免疫学
生物
内科学
环境卫生
作者
Arianna Brevi,Amir Zarrinpar
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2023-06-15
卷期号:83 (12): 1929-1932
被引量:3
标识
DOI:10.1158/0008-5472.can-22-2626
摘要
Almost every aspect of cancer can be influenced by microbiota including tumor onset, progression, and response to therapy. The increasing evidence of the role of microbiota in human health and disease has reinvigorated the interest in designing microbial products that can affect cancer outcomes. Researchers have made numerous attempts to develop safe, engineered biotherapeutic products for cancer treatment using synthetic biology tools. Despite the progress, only Bacillus Calmette-Guérin is approved for human use. Here, we highlight the recent advances and current challenges in using live bacteria as cancer therapeutics.
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