Study of the Effect of Preparation and Formulation Factors on the Stability of Vitamin C Microencapsulated by Solvent-Evaporation Method

This research studied the effect of formulation and processing variables on the stability of vitamin C or Ascorbic Acid (AA) encapsulated in Eudragit RS100 microparticles prepared using a solvent evaporation technique. Microparticles ranged in size from 60 to 102 μm and encapsulation efficiencies between 25% and 44% were obtained. Microencapsulation significantly enhanced the stability of AA compared to the free AA in solution. AA shelf life was extended up to 23 days. Increasing AA concentration and using sucrose or Tween 80 in the outer phase further enhanced AA stability. The results suggest that microencapsulation method under the investigated conditions is a promising approach for protecting AA from degradation in aqueous solutions.