化学
色谱法
废水
液相色谱-质谱法
串联质谱法
质谱法
检出限
废物管理
工程类
作者
Hang Ren,Sanyi Yuan,Jiaming Zheng,Ruxin Luo,Huosheng Qiang,Wenjia Duan,Yunli Zhao,Ping Xiang
标识
DOI:10.1016/j.chroma.2022.463587
摘要
The measurement of illicit drugs in wastewater is increasingly being adopted as a method for objective monitoring of population-level illicit drug use. This work describes the first small-volume direct-injection ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of 11 illicit drugs and metabolites in wastewater. The method required an injection volume of only 30 µL of wastewater sample, the limits of detection (LOD) ranged from 0.4 ng/L to 2 ng/L and the lower limits of quantitation (LLOQ) ranged from 1 ng/L to 5 ng/L. Application of the method to real wastewater samples collected from wastewater treatment plants revealed morphine in all samples, together with other illicit drugs (methamphetamine, codeine, ketamine, and nor-ketamine) in some samples. Small-volume direct injection showed great potential as an efficient method for the high-throughput determination of illicit drugs in wastewater.
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