佐剂
免疫系统
信使核糖核酸
核酸
抗原
CpG站点
CpG寡核苷酸
癌症免疫疗法
生物
化学
分子生物学
免疫疗法
癌症研究
免疫学
基因
基因表达
生物化学
DNA甲基化
作者
Yuhao Liu,Songhang Li,Shiyu Lin,Sirong Shi,Taoran Tian,Bowen Zhang,Tao Zhang,Yunfeng Lin
标识
DOI:10.1016/j.cclet.2022.107987
摘要
Synthetic antigen-encoding mRNA plays an increasingly significant role in tumor vaccine technology owing to its antigen-specific immune-activation. However, its immune efficacy is challenged by inferior delivery efficiency and demand for suitable adjuvants. Here, we develop a novel mRNA nanovaccine based on a multifunctional nanocapsule, which is a dual-adjuvant formulation composed of cytosine-phosphate-guanine motifs loaded tetrahedral framework nucleic acid (CpG-tFNA) and an immunopeptide murine β-defensin 2 (mDF2β). This mRNA nanovaccine successfully achieves intracellular delivery, antigen expression and presentation of dendritic cells, and proliferation of antigen-specific T cells. In a tumor prophylactic vaccination model, it exerts an excellent inhibitory effect on lymphoma occurrence through cellular immunity. This mRNA nanovaccine has promising prophylactic applications in tumors and many other diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI