Copper-Catalyzed Dienylation of Aldehydes Using Propargylic Carbonates

A copper-catalyzed dienylation of aldehydes using propargylic carbonates in the presence of B2pin2 has been successfully developed, enabling the synthesis of a diverse range of substituted 1,3-butadienyl-2-carbinols (BDCs). This innovative approach circumvents the requirement of allene reagents and provides an alternative protocol that allows access to BDCs. In addition, the synthetic value of the products has been demonstrated in a series of further conversions, and the reaction mechanism has been proposed based on control experiments.