Degradation of andrographolide in Andrographis paniculata over 1 year storage

Abstract Introduction Andrographolide is a bioactive component found in the medicinal herb Andrographis paniculata (Burm. f.) Wall. ex Nees (Family—Acanthaceae) is well‐known for its ability to cure liver disorders and as a bitter tonic. Objective In this study, the rate of degradation of andrographolide was examined over the course of a year of storage. Materials and methods New and old (1‐year storage) A. paniculata powder samples were used in the study. High‐performance liquid chromatography (HPLC) was used to assess the concentration of andrographolide after its extraction using ethanol as the solvent. Results The findings demonstrated a 69.26% progressive deterioration of andrographolide over the storage period. Temperature and crystallinity are two factors that affect how quickly andrographolide degrades. Conclusion The results emphasize how crucial it is to retain the effectiveness of A. paniculata extract by avoiding prolonged storage or by providing ideal storage conditions.