抗生素耐药性
抗生素
抗性（生态学）
医学
重症监护医学
生物
微生物学
生态学
作者
Wancai Que,Zixin Deng,Jiangtao Gao
标识
DOI：10.1016/j.molmed.2024.02.012
摘要
Abstract
In a recent report, Zampaloni et al. describe a novel tethered macrocyclic peptide (MCP) antibiotic, zosurabalpin, that disrupts the essential function of the LptB2FGC complex in Gram-negative bacteria and demonstrates efficacy against carbapenem-resistant Acinetobacter baumannii (CRAB). Its preclinical success suggests a substantial shift in treating antibiotic resistance, pending clinical trials to validate its effectiveness, pharmacokinetics, and resistance management.
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(2025-6-4)
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