白色念珠菌
真菌病原
生物相容性材料
病菌
微生物学
病原生物
纳米技术
量子点
材料科学
生物
医学
生物医学工程
作者
Anam Rais,Shubham Sharma,Prashant Mishra,Luqman Ahmad Khan,Tulika Prasad
出处
期刊:Nanomedicine
日期:2024-03-01
标识
DOI:10.2217/nnm-2023-0292
摘要
Aim: The development of carbon quantum dots (C-QDs) as nanotrackers to understand drug–pathogen interactions, virulence and multidrug resistance. Methods: Microwave synthesis of C-QDs was performed using citric acid and polyethylene glycol. Further, in vitro toxicity was evaluated and imaging applications were demonstrated in Candida albicans isolates. Results: Well-dispersed, ultra small C-QDs exhibited no cyto/microbial/reactive oxygen species-mediated toxicity and internalized effectively in Candida yeast and hyphal cells. C-QDs were employed for confocal imaging of drug-sensitive and -resistant cells, and a study of the yeast-to-hyphal transition using atomic force microscopy in Candida was conducted for the first time. Conclusion: These biocompatible C-QDs have promising potential as next-generation nanotrackers for in vitro and in vivo targeted cellular and live imaging, after functionalization with biomolecules and drugs.
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