化学
环加成
原位
钯
催化作用
有机化学
酰化
组合化学
作者
Yongqiang Dong,Sen Yang,Yi Tang,Kuan Li,Jun Liu,Fazhou Yang,Cheng Zhang,Hongchao Guo
标识
DOI:10.1021/acs.orglett.4c00315
摘要
In this paper, palladium-catalyzed [3 + 2] cycloaddition of 4-vinyl-4-butyrolactones with ketenes generated from easily available acyl chlorides was achieved. With Pd2(dba)3·CHCl3/XantPhos as the catalyst, the reaction proceeded smoothly under mild reaction conditions, affording a series of 2,3-dihydrofurans in moderate to high yields. The scale-up reaction and further transformations of the products are demonstrated, and a plausible mechanism is proposed as well.
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