The causes and outcomes of Implantable Collamer Lens explantation in patients with corneal endothelial cell loss.

Purpose: To investigate the correlated factors of corneal endothelial cell density (ECD) loss and ECD change in Implantable collamer lens (ICL) explantation patients. Setting: Seoul St. Mary’s hospital, Seoul, Republic of Korea Design: Retrospective analysis Method: The study cohort consisted of 93 eyes from 50 patients who underwent ICL explantation. Correlation analysis was performed to assess the ocular parameters associated with ECD loss, while percentage of ECD change (ΔECD%) was monitored up to 6months postoperatively. Receiver operating characteristic (ROC) curve was used to set cutoff values of ocular parameters to prevent ECD loss after explantation. Results: In multiple regression analysis, high vaulting, high vaulting/anterior chamber depth (ACD), low anterior chamber angle (ACA), and high iris pigmentations are the significant factors of ECD loss. At postoperative 6months, 14 eyes (15.1%) had decrease (10.5% loss), 47 eyes (51.0%) were stationary, and 32 eyes (34.4%) had increase (12.7% gain) of ECD. The ROC curve analysis showed that vaulting had the highest area under the curve (AUC=0.822), followed by vaulting/ACD (AUC=0.821), ECD (AUC=0.753), and ACA (AUC=0.723) (all p<0.01). Preoperative ECD showed a sensitivity of 77.6% and specificity of 86.7% in preventing ECD loss after explantation, with a cutoff value of 1722 cells/mm 2 , as determined by ROC curve analysis. Conclusion: Our study demonstrated that high vaulting is a significant factor in ECD loss among ICL inserted patients. To prevent continuous ECD loss in ICL patients, close monitoring of ECD and making appropriate decisions regarding explantation may be necessary.