Mammographic Calcifications Add Uncertainty in Predicting Response to Neoadjuvant Chemotherapy

HomeRadiologyVol. 316, No. 3 PreviousNext Reviews and CommentaryEditorialMammographic Calcifications Add Uncertainty in Predicting Response to Neoadjuvant ChemotherapyLars J. Grimm1 Lars J. Grimm1 Author Affiliations1Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710Address correspondence to: the author (email: [email protected]).Lars J. Grimm1 Published Online:Sep 9 2025https://doi.org/10.1148/radiol.252363See also the article by Ko and Yu et al in this issue.MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In References1. Portnow LH, Kochkodan-Self JM, Maduram A, et al. Multimodality imaging review of HER2-positive breast cancer and response to neoadjuvant chemotherapy. RadioGraphics 2023;43(2):e220103. Google Scholar2. Reig B, Lewin AA, Du L, et al. Breast MRI for evaluation of response to neoadjuvant therapy. RadioGraphics 2021;41(3):665–679. Google Scholar3. Johnson KS, Conant EF, Soo MS. Molecular subtypes of breast cancer: a review for breast radiologists. J Breast Imaging 2021;3(1):12–24. Medline Google Scholar4. Ko ES, Yu JH, Woo SY, et al. Calcifications affect pathologic complete response and MRI prediction after neoadjuvant chemotherapy in human epidermal growth factor receptor 2–positive breast cancer. Radiology 2025;316(3):e250718. Google Scholar5. Vidavsky N, Kunitake JAMR, Estroff LA. Multiple pathways for pathological calcification in the human body. Adv Healthc Mater 2021;10(4):e2001271. Medline Google Scholar6. Feng K, Jia Z, Liu G, et al. A review of studies on omitting surgery after neoadjuvant chemotherapy in breast cancer. Am J Cancer Res 2022;12(8):3512–3531. Medline Google Scholar7. Gampenrieder SP, Peer A, Weismann C, et al. Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR). Breast Cancer Res 2019;21(1):19. Medline Google ScholarArticle HistoryReceived: July 31 2025Revision requested: Aug 5 2025Revision received: Aug 8 2025Accepted: Aug 8 2025Published online: Sept 09 2025 FiguresReferencesRelatedDetailsAccompanying This ArticleCalcifications Affect Pathologic Complete Response and MRI Prediction after Neoadjuvant Chemotherapy in Human Epidermal Growth Factor Receptor 2–positive Breast CancerSep 9 2025Radiology Vol. 316, No. 3 Metrics Altmetric Score PDF download