Zeolitic Imidazolate Framework‐8 as a pH‐Responsive Smart Targeted Release Nanoplatform for Antibacterial Therapy and Wound Regeneration

The biomedical domain has witnessed a significant incorporation of nanotechnology in recent years. Zeolitic imidazolate framework-8 (ZIF-8) has demonstrated potential as a pH-responsive smart targeted release nanoplatform for antibacterial and anti-inflammatory agents, attributed to its superior biocompatibility and robust physicochemical stability. Furthermore, the high porosity and substantial surface area of ZIF-8 enable significant drug-loading capacity and the encapsulation of various agents, including small inorganic molecules and large protein molecules. Moreover, ZIF-8 composite materials exhibit unique pH sensitivity and photosensitivity, resulting in decomposition and subsequent release of antibacterial and anti-inflammatory agents under acidic conditions and near-infrared irradiation, respectively. This review aims to synthesize recent advancements in pH-responsive and photosensitive ZIF-8 as a dual-responsive smart targeted release nanoplatform in antibacterial therapy and wound regeneration. Furthermore, this review elucidates the benefits and operational principles of ZIF-8 as a smart targeted release nanoplatform for antibacterial efficacy and wound healing, with the objective of providing a comprehensive rationale and guidance for investigations into the antibacterial properties and the promotion of wound regeneration facilitated by ZIF-8.