Solvent-free stereoselective synthesis of phosphoenolpyruvates and their C-P and N-P analogues

Phosphoenolpyruvate is widely involved in a variety of biochemical processes. Herein we report a facile synthetic method for phosphoenolpyruvates and their C-P and N-P analogues via the classic Perkow reaction under mild solvent-free conditions. A moderate to excellent E/Z-stereoselectivity was observed giving the E-isomer as the main product, as determined by full NMR spectroscopy analysis.