Intervening GSK3 Signaling Attenuates Cutaneous Inflammation and Itch in Mice: Implication for Future Therapeutic Development

Chronic itch diseases, such as atopic dermatitis (AD), represent major challenges of modern medicine (Kim, 2022). There is an evident gap toward basic understanding and suitable targets for the diseases. The complex heterogeneity of itch causes and presentations and insufficient evidence of animal models are obstacles to effective drug development. Among the known pruritogens in AD, adaptive (e.g., T helper 2) immune cells release IL-4, IL-13, and IL-31 to activate cytokine receptors on nerve endings.