荧光
四苯乙烯
极性(国际关系)
分子内力
芘
肿瘤微环境
化学
癌细胞
生物物理学
癌症
生物化学
立体化学
物理
有机化学
生物
聚集诱导发射
细胞
遗传学
量子力学
作者
Chuthamat Duangkamol,Prapassara Muangsopa,Sopita Rattanopas,Pornpimol Wongsuwan,Tunyawat Khrootkae,Piyasiri Chueakwon,Nakorn Niamnont,Kantapat Chansaenpak,Anyanee Kamkaew
标识
DOI:10.1016/j.dyepig.2023.111365
摘要
Fluorescent probes sensitive to microenvironments have constantly been attractive, due to their significant benefits in monitoring changes in the pathophysiological microenvironment and their use in the early detection of associated disorders. In this work, we explored three new molecular rotors that could be potential candidates for detecting lipid droplets (LDs) in cancer cells based on coumarin derivatives connected with electron-donating polycyclic units including, tetraphenylethylene (LD-TPE), pyrene (LD-PYR), and 4,5-diphenylimidazole (LD-DIP). Gratifyingly, LD-PYR showed exceptional polarity and viscosity sensitivity and demonstrated bright fluorescence in highly viscous environments due to the suppression of the twisted intramolecular charge transfer (TICT) phenomenon and intramolecular rotation. Moreover, microenvironment-guided specific LD bioimaging by LD-PYR exhibited a reasonable ability to distinguish between cancer and noncancer cells. These data suggested that LD-PYR has interesting clinical diagnostic and microenvironment-related biological applications.
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