Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system

Lipid-based formulation (LBF) has attracted more and more attention as it can significantly improve the efficiency of oral delivery of poorly soluble drugs by exploiting the specific absorption pathway of lipids in the intestinal lymphatic system. Based on the structure and function of the intestinal lymphatic system, this article describes the advantages and strategies of oral LBF delivery through this system, highlights the research progress of oral LBF (lipid-based nanocarriers, lipid-based prodrugs) based on this system in recent years, and briefly outlines the experimental model to study the intestinal lymphatic delivery of drugs, providing methods and ideas for the development and utilization of poorly soluble drugs and the rational design of LBF.