生物
谱系(遗传)
表观基因组
表型
细胞生物学
癌症研究
遗传学
基因
DNA甲基化
基因表达
作者
Shuheng Lin,Raphaël Margueron,Emmanuelle Charafe‐Jauffret,Christophe Ginestier
标识
DOI:10.1016/j.tcb.2023.03.010
摘要
Increase in lineage infidelity and/or imbalance is frequently observed around the earliest stage of breast tumor initiation. In response to disruption of homeostasis, differentiated cells can partially lose their identity and gain cellular plasticity, a process involving epigenome landscape remodeling. This increase of cellular plasticity may promote the malignant transformation of breast tumors and fuel their heterogeneity. Here, we review recent studies that have yield insights into important regulators of lineage integrity and mechanisms that trigger mammary epithelial lineage derail, and evaluate their impacts on breast tumor development.
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